In recent years, prescription weight loss injections have gained huge attention, and two treatments in particular are leading the way: Mounjaro and Wegovy. Both have shown impressive results in clinical trials, helping patients lose a significant amount of their body weight. While they share some similarities, the way they work and the results they deliver aren’t identical.
If you’re considering a medical option to support weight loss, understanding the key differences between these two treatments can help you make an informed choice.
Wegovy: The Semaglutide Option
Wegovy is the brand name for semaglutide, a once-weekly injection that mimics a natural hormone in the body called GLP-1. This hormone regulates appetite by slowing digestion and making you feel fuller for longer.
In clinical studies, people taking Wegovy alongside diet and exercise lost up to 17% of their body weight over 68 weeks. While results vary, this makes Wegovy one of the most effective weight loss medications currently licensed in the UK.
Mounjaro: The New Contender
Mounjaro (tirzepatide) is another weekly injectable, but it works slightly differently. Instead of targeting just the GLP-1 hormone, it also activates a second hormone called GIP. Together, these hormones help regulate appetite, blood sugar, and fat metabolism.
In head-to-head clinical data, Mounjaro has shown even greater results than Wegovy. Patients taking Mounjaro lost up to 22.5% of their body weight over 72 weeks, making it the most effective weight loss medication available in the UK.
Head-to-Head: Which Works Better?
When comparing the two, the figures speak for themselves:
- Wegovy: up to 17% weight loss in 68 weeks
- Mounjaro: up to 22.5% weight loss in 72 weeks
On paper,Mounjaro delivers greater average weight loss. However, real-world results can vary significantly between individuals. Factors such as diet, exercise, underlying health conditions, and adherence to treatment all play a role.
Side Effects to Keep in Mind
Like all medications, both treatments can cause side effects. The most commonly reported issues withWegovy include nausea, constipation, diarrhoea, and occasional vomiting, particularly as the dose is gradually increased during the first few months of treatment.
Mounjaro shares a similar side effect profile, with digestive symptoms being the most frequent. Some patients find that adjusting their diet, by avoiding foods that are particularly fatty, fried, or spicy, for example, can help reduce discomfort. For most people, these side effects are temporary and tend to settle as the body adapts to treatment.
How They’re Taken
BothMounjaro andWegovy are designed for ease of use. Each comes as a pre-filled pen for self-injection once a week. The medication is injected just under the skin, usually in the stomach, thigh, or upper arm.
It’s recommended to rotate injection sites each week to reduce the risk of irritation. Both pens are designed with convenience in mind, making it straightforward for patients to administer the injections at home without medical assistance.
So… Which One Should You Pick?
Choosing betweenWegovy andMounjaro depends on your personal health profile, weight loss goals, and how your body responds to treatment. While Mounjaro has shown greater average results in clinical trials, Wegovy has already helped thousands of patients achieve substantial and sustainable weight loss.
Both are prescription-only medicines, so the decision should always be made with the guidance of a healthcare professional.
If you’re ready to explore your options,Pharmica, a fully UK-registered online pharmacy, offers secure online consultations for both treatments. Once approved, medication is delivered discreetly to your door, with expert support available whenever you need it.
The bottom line: Wegovy is a tried-and-tested option with impressive results, while Mounjaro represents the next step forward in medical weight management. Both can be highly effective. The best choice is the one that fits your health needs and long-term goals.